PCN248 Productivity Costs Associated with Disease Recurrence Among Surgically-Treated Patients with Triple-Negative Breast Cancer

In addition to direct healthcare costs, cancer patients incur productivity costs due morbidity and mortality. This study evaluated associated with TNBC recurrence among surgically-treated patients. Eligible were identified from the OptumHealth Reporting Insights database grouped into non-recurrence cohorts. Patients classified as metastatic or locoregional based on claims observed after surgery. For recurrent patients, index dates defined 30 days before recurrence; for non-recurrent they randomly assigned. Productivity disability employers' payments; medically-related absenteeism calculated using of wage data. Multivariable regression models used compare loss costs. The considered period up one year post-index. Cox proportional hazard compared risk leaving workforce over five years date. All adjusted controlled baseline characteristics. 412 838 (both non-recurrent) included in workloss analyses, respectively. analysis, total 1.51 2.08 times higher, respectively, than cohort p<0.001). Predicted monthly $451 without recurrence, $849 $1,454 recurrence. Adjusted found cost differences between cohorts be statistically significant addition, a 63% higher rate (p=0.003), primarily driven by leave absence short- long-term disability. is decreased workforce. analysis contributes limited literature addressing productivity-related impact